I know people use cracked skillets for things like cornbread, so you might use it for biscuits.
If you were just going to be using it for roasting vegetables, or maybe baking a whole bunch of cut up potatoes, I would say you could probably get away with it. If during cooking the crack extended all the way to the bottom or even if the whole DO split, not a major problem. I would also not lift it by the handles as it would add stress to the crack, and you don't want it to break while lifting it.
I would NOT cook a large pot of chili, stew, or soup in it. There is a chance that it could split, and you end up with a large amount of extremely hot liquid pouring out all over the place.